Important question to be addressed by future research, especially in light of the growing interest in applying immunotherapies Whether immune alterations drive schizophrenia progression is an Genes that also regulate brain development and plasticity. Instead, there may be a role for pleiotropic effects of a small number of immune Major role in schizophrenia susceptibility. In support of the immune hypothesis, they suggest that genetically mediated alterations in immune function may not play a While our findings do not refute evidence that has accumulated Among 108 regions of the genome previouslyĪssociated with schizophrenia, we identify 6 immune candidates (DPP4, HSPD1, EGR1, CLU, ESAM, NFATC3) encoding proteins with alternative, nonimmune roles in the brain. Of schizophrenia conducted to date, in contrast to 5 diseases of known immune origin.
We show that there is no enrichment of immune loci outside of the MHC region in the largest genetic study Here we empirically test the hypothesis that variation in immune genes contributes Pathway analyses provide inconsistent evidence of immune involvement in schizophrenia, and it remains unclear whether geneticĭata support an immune etiology per se. (GWASs) of schizophrenia and has been interpreted as strong genetic evidence supporting the immune hypothesis. The major histocompatibility complex is consistently the most powerful region of association in genome-wide association studies There has been intense debate over the immunological basis of schizophrenia, and the potential utility of adjunct immunotherapies.
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